Scott began his professional career in 1969 in the Canadian Football League as a defensive back and kick returner with the BC Lions. He was drafted by the Dolphins in seventh round of the 1970 NFL Draft, where in his rookie year, he made five interceptions for 112 yards and made one touchdown in a punt return. The following year, he recorded seven interceptions and 318 punt return yards, assisting the team to Super Bowl VI.
Scott was a key member of the 1972 Miami Dolphins undefeated season, and finished that season as Super Bowl MVP of Super Bowl VII, recording two interceptions and 63 return yards in the Dolphins' 14-7 win over the Washington Redskins including one in the fourth quarter. He also played for the Dolphins in their 24-7 Super Bowl VIII win, recording a fumble recovery, 20 punt return yards, and 47 kickoff return yards in that game.
Overall, Scott recorded 35 interceptions in his six seasons as a Dolphin, which makes him the Dolphins all-time leader in that category.
Scott wore number 13 throughout his career (a number not worn by NFL safeties today), which was later made famous in Miami by Dan Marino, and has since been retired in Marino's honor.
Jake Scott was inducted along with his former college roommate Bill Stanfill into the Dolphin Honor Roll on November 18, 2010.